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Assay Reference Intervals

Tests APTT PT TCT Fibrinogen D dimer Antithrombin Protein C
Units (seconds) (seconds) (seconds) mg/dL ng/mL (%) (%)
Species
Canine 11.0 - 17.5 11.0 - 15.5 5.0 - 9.0 150 – 490 0 - 575 65 - 145 75 - 135
Feline 15.0 – 21.0 15.0 – 20.0 5.0 – 8.0 76 – 270 0 – 250 75 - 100 65 - 120
Equine 35.8 – 48.6 11.0 – 15.0 200 – 470 0 – 1000 85 - 130
Bovine 30.0 – 58.0 26.0 – 38.0 440 - 770
Alpaca 16.6 – 22.1 10.9 – 13.6 128 - 327
Rat (SD) 12.1 – 22.5 18.7 – 28.0 145 - 340
Dolphin 230 - 325

Assay Information

Test Assay
aPTT activated partial thromboplastin time; 3 minute activation time, ellagic acid reagent
PT prothrombin time; rabbit brain thromboplastin reagent
TCT thrombin clotting time; bovine thrombin reagent
Fibrinogen Clauss (clottable) fibrinogen; same species standard (canine, feline, equine) all others human standard
Antithrombin anti-IIa activity, chromogenic substrate; same species standard (canine, feline, equine) all others human standard
D dimer D dimer concentration, immunoturbidometric assay; human D dimer standard
Protein C snake venom activator, chromogenic substrate; same species standard (canine, feline) all others human standard