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Baker Institute for Animal Health

DEDICATED TO THE STUDY OF VETERINARY INFECTIOUS DISEASES, IMMUNOLOGY, GENETICS, AND REPRODUCTION

Parvovirus capsid structures and interactions with receptors and antibodies

Colin R. Parrish, Ph.D.
Baker Institute for Animal Health
235 Hungerford Hill Road

Ithaca, NY 14853
Phone: (607) 256-5610
Fax: (607) 256-5608
crp3@cornell.edu

Our studies of host range are examining the sequence of events which lead to infection of restriction of the different virus capsids - i.e. transport into the correct pathway for infection; disassembly of the virus capsid in the appropriate cellular compartment; and the transport of the capsid or viral DNA to the nucleus in a form which allows productive infection. These studies will include definition of the endocytic uptake pathways which are used by the viruses during the process of cell entry and infection (as described above), but characterizing the cellular molecules which act on the virus. We find that the capsids follow a variety of endocytic pathways within the cells.

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