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Molecular and Integrative Physiology

The study of physiology covers a broad range of investigations under the umbrella of "how living organisms function."  The PhD program in Molecular and Integrative Physiology offers a comprehensive program of study and research opportunities emphasizing training in molecular/genomic aspects of cell, organ and whole animal physiology, with an emphasis on physiological genomics. The program of study provides an outstanding foundation in physiological mechanisms at the cellular, tissue, organ and whole animal level, and how these mechanisms interface with molecular and genetic aspects.

Students have the opportunity to concentrate in the following areas: reproductive physiology and genomics; cardiovascular physiological genomics; endocrinology; environmental and comparative physiology; gastrointestinal and metabolic physiological genomics; membrane and epithelial physiology; neural and sensory physiological genomics.

Admission

Since MIP is a part of the Biological & Biomedical Sciences Graduate Program (BBS), applicants to the Field should follow the BBS application guidelines. MIP requires two (2) letters of recommendation.

Faculty


Carolyn Adler

Regeneration; stem cell biology; tissue homeostasis; transcriptional regulation of cell differentiation


Elizabeth Adkins-Regan

Behavioral physiology; endrocrinology; reproductive physiology


Dorothy Ainsworth
Cardiovascular and respiratory physiology

Douglas Antczak
Cellular transport mechanisms and electrolyte regulation; NaCl secretion in renal tubules

Adam Boyko
Genetics of domestication and rapid adaptation; canine genomics; evolutionary and population genetics; bioinformatics

W. Ron Butler
Reproductive physiology - gonadotropins and ovarian function; reproduction/nutrition interactions


Paula Cohen

Etiology of spontaneous birth defects in mammals; mechanisms of meiotic recombination; DNA repair proteins in meiosis and recombination; germ cell development; ovarian development


Scott Coonrod

Reproductive physiology; molecular and cellular physiology; the role that novel, highly abundant and egg-restricted molecules play in epigenetic reprogramming during the egg-to-embryo transition; mechanisms by which specific histone modifications are dynamically regulated during hormone-dependent gene transcription in breast cancer cells


Bethany Cummings

Obesity, insulin resistance and type 2 diabetes pathogenesis and treatment; development and study of rodent models of bariatric surgery


Robin Dando

Behavioral physiology; molecular and cellular physiology; neural and sensory physiology; physiological genomics; neurotransmitter interactions and signaling events which occur within the taste system

Scott Emr
Regulation of cell signaling and membrane trafficking pathways by phosphoinositide kinases; protein kinases; ubiquitin modifications; vesicle-mediated transport reactions

Claudia Fischbach-Teschl
Tissue-engineered model systems for analysis of microenvironmental conditions fundamental to cancer pathogenesis and therapy

Maria Garcia-Garcia
Developmental biology in mice and flies; genetics of development mechanisms that influence embryonic morphology

Cole Gilbert
Neural mechanisms of behavior in arthropods

Robin Gleed
Respiration, hypoxea, and pulmonary circulation; anesthesiology

Ron Harris-Warrick
Cellular and synaptic mechanisms that shape network function and motor output from Central Pattern Generator circuits

Patricia Johnson
Endocrinology; reproductive physiology

Michael Kotlikoff
Cardiovascular and respiratory physiology; molecular and cellular physiology


Natasza Kurpios

Study of signaling pathways that direct organogenesis of vertebrates to determine distinct cellular behaviors and cell shape during development

Cynthia Leifer
Regulation of innate immune receptors such as Toll-like receptors (TLRs); role of TLRs in autoimmunity, initiation of inflammatory responses to microbial infection, development of molecular and cellular, as well as whole animal models to study the biology of TLRs
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Sergiy Libert
Mice; molecular biology of aging; age-associated diseases; cancer; neurodegeneration; anorexia; energy metabolism

David Lin
Axon guidance and target formation during the development of the mouse olfactory system, using genetic, in vitro, and genomic approaches

Ellis Loew
Physiology of vision; sensory biophysics; sensory ecology and nutritional ophthalmology

Marla Lujan
Nutritional regulations of female reproduction


Vicki Meyers-Wallen

Developmental biology; genetics; reproductive biology


Alexander Nikitin

Genetic modeling of human cancer in the mouse; early detection and monitoring of carcinogenesis; neoplasms of reproductive and endocrine systems


Linda Nowak

Membrane biophysics; molecular biology of glutamate receptors; cellular neurophysiology; pharmacology of synaptic transmission

Kimberly O'Brien
Calcium metabolism and bone health; control of maternal/fetal nutrient; partitioning and cellular mineral transport; micronutrient status in international settings; development of mass spectrometric methodology; pediatric bone health; pregnancy and mineral metabolism in adolescents


Ned Place

Mammalian reproductive biology with a focus on the life history of trade-offs associated with timing of hormone secretion and reproductive effort; sexual differentiation

Shu-Bing Qian
Nutrient signaling pathway, stress response, protein synthesis, and their implications on human disease


Susan Quirk

Reproductive physiology; focus on molecular and cellular aspects of ovarian function


Mark Roberson

Reproductive physiology; endocrinology; molecular and cellular physiology

Chris Schaffer
Advanced optical techniques used to observe and manipulate in vivo biological systems with the goal of developing microscopic scale understanding of normal and disease-state physiological processes


John Schimenti

Molecular and cellular physiology; physiological genomics; reproductive physiology; mouse genetics and functional genomics; genomic instability; genetic recombination; genetics of gometogenesis and development; use of ES cells to mutagenize the mouse genome

Vimal Selvaraj
Mammalian reproductive physiology; stem cells; technologies for wildlife conservation - Blog


Carolyn Sevier

Characterization of the signaling pathways that sens and respond to cellular redox imbalances to alleviate oxidative stress


Alexander Travis

Biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft subdomains in sperm; conservation applications of germ cell reproductive technologies

Robert Weiss
Genomic maintenance mechanisms; cell cycle checkpoints; molecular responses to genomic stress; mouse models of genomic instability


Mariana Wolfner

Molecular and genetic mechanisms of reproductive processes, specifically, functions and evolution of seminal proteins and (separately) mechanisms of egg activation and early embryogenesls

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