Edward Dubovi

Faculty member

Department of Population Medicine and Diagnostic Sciences

Professor

Department of Population Medicine and Diagnostic Sciences
Cornell University College of Veterinary Medicine
Ithaca, NY 14853

Office: 607.253.3923
Fax: 607.253.3627
Email: ejd5@cornell.edu

Research Interest

Dr. Dubovi's main areas of research include viral diseases of cattle with particular emphasis on bovine viral diarrhea virus, viral diseases of dogs with emphasis on canine influenza virus, and viral diseases of domestic animals that impact endangered wildlife. Within the context of the Department of Population Medicine and Diagnostic Sciences, current efforts also included herd health programs that emphasize biosecurity and effective use of veterinary biologicals.

Education

  • B.A. - Biology, 1967 University of Pennsylvania - Philadelphia, PA
  • M.A. - Virology, 1968 Purdue University - West Lafayette, IN
  • Ph.D.. - Microbiology, 1975 University of Pittsburgh School of Medicine - Pittsburgh, PA

Biography/Professional Experience

  • 10/04-present Professor of Virology
  • 3/02-4/03 Associate Director for Laboratory Operations, Animal Health Diagnostic Laboratory, Dept of Pop Med and Diag. Science, College of Veterinary Medicine at Cornell.
  • 2/01-3/02 Associate Chair of Diagnostic Programs, Dept of Pop Med and Diag. Science, College of Veterinary Medicine at Cornell.
  • 7/98-7/99 Associate Chair of Diagnostic Programs, Dept of Pop Med and Diag Science, College of Veterinary Medicine at Cornell.
  • 7/90-7/98 Associate Director, Diagnostic Center, College of Veterinary Medicine at Cornell
  • 11/87-9/04 Associate Professor, Dept Pop Med and Diag Science, College of Veterinary Medicine at Cornell
  • 11/81-11/87 Assistant Professor, Diagnostic Laborartory, New York State College of Veterinary Medicine at Cornell.
  • 9/77 - 11/81 Research Assistant Professor of Pediatrics and Bacteriology, University of North Carolina at Chapel Hill.
  • 7/76 - 8/77 U.S.P.H.S. Research Fellowship, Department of Microbiology, School of Medicine, University of Virginia.

Publications

  • Woodroffe R, Prager KC, Munson L, Conrad PA, Dubovi EJ, Mazet JA. 2012. Contact with Domestic Dogs Increases Pathogen Exposure in Endangered African Wild Dogs (Lycaon pictus). PLoS One. 7 (1):e30099. Epub 2012 Jan 6.
  • Goodman LB, Wimer C, Dubovi EJ, Gold C, Wagner B. Immunological correlates of vaccination and infection for equine herpesvirus type 1. Clin Vaccine Immunol. 2011 Dec 28. [Epub ahead of print].
  • Allison AB, Harbison CE, Pagan I, Stucker KM, Kaelber JT, Brown JD, Ruder MG, Keel MK, Dubovi EJ, Holmes EC, Parrish CR. 2012. Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus. J Virol. 86 (2):865-72. Epub 2011 Nov 9.
  • Kapoor A, Mehta N, Dubovi EJ, Simmonds P, Govindasamy L, Medina JL, Street C, Shields S, Lipkin WI. 2011. Characterization of Novel Canine Bocaviruses and their Association with Respiratory Disease. J Gen Virol. 93:341-6
  • Digangi BA, Gray LK, Levy JK, Dubovi EJ, Tucker SJ. 2011. Detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care ELISA. J Feline Med Surg. 13 (12):912-8. Epub 2011 Aug 31.
  • Kapoor A, Simmonds P, Dubovi EJ, Qaisar N, Henriquez JA, Medina J, Shields S, LipkinWI. 2011. Characterization of a canine homolog of human Aichivirus. J Virol. Nov;85 (21):11520-5. Epub 2011 Aug 31.
  • Burbelo PD, Dubovi EJ, Simmonds P, Medina HL, Henriquez JA, Mishra N, WagnerJ, Tokaz R, Cullen JM, Landarola MJ, Rice CM, Lipkin WI, Kapoor A. 2012. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol. 86:6171-8
  • Lister AL, Pressler B, Volpe A, Dubovi E. 2012. Accuracy of point-of-care ELISA test kit for predicting he presence of protective canine parvovirus and canine distemper virus antibody concentrations in dogs. Vet J. Feb 28.
  • Pinto P, Wang Q, Chen N, Dubovi EJ, Daniels JB, Millward LM, Buonavoglia C, Martella V, Saif LJ. 2012. Discovery and genomic characterization of notoviruses from a gastroenteritis outbreak in somestic cats in the US. PLoS One. 7(2):e32739.
  • Gray LK, Crawford PC, Levy, Dubovi EJ. 2012. Comparison of two assays for detection of antibodies against canine parvovirus and canine distemper virus in dogs admitted to a Florida animal shelter. J am Vet Med Assoc. May 1;240(9):1084-7
  • Anderson TC, Crawford PC, Katz JM, Dubovi EJ, Landolt G, Gibbs EP. 2012. Diagnostic performance of the canine influenza A virus subtype H3N8 hemagglutination inhibition assay. J Vet Diagn Invest 24(3):499-508.
  • Regan AD, Millet JK, Tse LP, Chilag Z, Rinaldi VD, Licitra BN, Dubovi EJ, Town CD, Whittaker GR. 2012. Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain. Virology 430(2):90-9.
  • Kapoor A, Dubovi EJ, Henriquez-Rivera JA, Lipkin WI. 2012. Complete genome sequence of the first canine circovirus. J Virol 86(12):7018.
  • Kirchgessner MS, Dubovi EJ, Porter WF, Zylich, NC, Whipps CM. 2012. Prevalence and spatial distribution of antibodies to bovine viral diarrhea virus and Coxiella burnetii in white-tailed deer (Odocoileus virginianus) in New York and Pennsylvania. J Zoo Wildl Med: 43(3);466-72..
  • Renshaw RW, Wise A, Maes R, Dubovi EJ. 2012. Complete genome sequence of a polyomavirus isolated from horses. J Virol 86(16):8903.
  • DiGangi BA, Levy JK, Griffin B, McGorray SP, Dubovi EJ, Dingman PA, Tucker SJ. 2012. Prevalence of serum antibody titers against feline panleukopenia virus, feline herpesvirus 1, and feline calicivirus in cats entering a Florida animal shelter. J Am Vet Med Assoc. 2012 Nov 15;241(10):1320-5. doi: 10.2460/javma.241.10.1320
  • Anderson TC, Crawford PC, Dubovi EJ, Gibbs EP, Hernandez JA 2013. Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States. J Am Vet Med Assoc. 2013 Jan 15; 242(2):209-16. doi: 10.2460/javma.242.2.209. PubMed PMID: 23276098.
  • Nikolin VM, Osterrieder K, von Messling V, Hofer H, Anderson D, Dubovi E, Brunner E, East ML. 2012. Antagonistic pleiotropy and fitness trade-offs reveal specialist and generalist traits in strains of canine distemper virus. PLoS One. 2012;7(12):e50955. doi: 10.1371/journal.pone.0050955. Epub 2012 Dec 11. PubMed PMID: 23239996; PubMed Central PMCID: PMC3519774.
  • Allison AB, Kohler DJ, Fox KA, Brown JD, Gerhold RW, Shearn-Bochsler VI, Dubovi EJ, Parrish CR, Holmes EC. 2012. Frequent Cross-Species Transmission of Parvoviruses Among Diverse Carnivore Hosts. J Virol. 2012 Dec 5. [Epub ahead of print] PubMed PMID: 23221559.
  • Kirchgessner MS, Dubovi EJ, Porter WF, Zylich NC, Whipps CM. 2012. Disease risk surface for Coxiella burnetii seroprevalence in white-tailed deer. 2012. Zoonoses Public Health. Nov 26. Doi: 10.1111/zph. 12023.
  • Keller SM, Gabriel M, Terio KA, Dubovi EJ, VanWormer E, Sweitzer R, Barret R, Thompson C, Purcell K, Munson L. 2012. Canine distemper in an isolated population of fishers (Martes pennanti) from California. J Wildl Dis. 2012 Oct;48(4):1035-41. doi:10.7589/2011-12-350. PubMed PMID: 23060505.
  • Ledbetter EC, da Silva EC, Kim SG, Dubovi EJ, Schwark WS. 2012. Frequency of spontaneous canine herpesvirus-1 reactivation and ocular viral shedding in latently infected dogs and canine herpesvirus-1 reactivation and ocular viral shedding induced by topical administration of cyclosporine and systemic administration of corticosteroids. Am J Vet Res. 2012 Jul;73(7):1079-84. doi: 10.2460/ajvr.73.7.1079. PubMed PMID: 22738061.
  • Anderson DE, Dubovi EJ, Yu M, Wang LF, Renshaw RW. 2012. Genome characterization of Salem virus reveals its evolutionary intermediate status in the subfamily Paramyxovirinae. Arch Virol. 2012 Oct;157(10):1989-93. Epub 2012 Jun 23. PubMed PMID: 22729563.
  • Kirchgessner MS, Dubovi EJ, Whipps CM. 2012. Seroepidemilogy of Coxiella burnetii in wild white-tailed deer (Ondocolileus virginianus) in New York. Vector Borne Zoonotic Dis. Nov;12(11):942-7. doi:10.1089/vbz.2011.0952
  • Prager KC, Mazet JA, Dubovi EJ, Frank LG, Munson L, Wagner AP, Woodroffe R. 2012. Rabies virus and canine distemper virus in wild and domestic carnivores in Northern Kenya: are domestic dogs the reservoir? Ecohealth. 2012 Dec;9(4):483-98. doi: 10.1007/s10393-013-0815-9. Epub 2013 Mar 5.
  • Kirchgessner MS, Dubovi EJ, Whipps CM. 2013. Spatial point pattern analyses of Bovine viral diarrhea virus infection in domestic livestock herds and concomitant seroprevalence in wild white-tailed deer (Odocoileus virginianus) in New York State, USA. J Vet Diagn Invest. 2013 Mar; 25(2):226-33. doi: 10.1177/1040638713479121.
  • Glineur SF, Renshaw RW, Percopo CM, Dyer KD, Dubovi EJ, Domachowske JB, Rosenberg HF. 2013. Novel pneumoviruses (PnVs): Evolution and inflammatory pathology. Virology. 2013 Sep 1; 443(2):257-64. doi: 10.1016/j.virol.2013.05.011. Epub 2013 Jun 10.
  • Dubovi EJ, Hawkins M, Griffin RA Jr, Johnson DJ, Ostlund EN. 2013. Isolation of Bluetongue virus from canine abortions. J Vet Diagn Invest. 2013 Jul;25(4):490-2. doi: 10.1177/1040638713489982. Epub 2013 Jun 18.
  • Epstein JH, Baker ML, Zambrana-Torrelio C, Middleton D, Barr JA, Dubovi E, Boyd V, Pope B, Todd S, Crameri G, Walsh A, Pelican K, Fielder MD, Davies AJ, Wang LF, Daszak P. 2013. Duration of Maternal Antibodies against Canine Distemper Virus and Hendra Virus in Pteropid Bats. PLoS One. 2013 Jun 27;8(6):e67584. Print 2013.
  • Mitchell JA, Cardwell JM, Renshaw RW, Dubovi EJ, Brownlie J. 2013. Detection of canine pneumovirus in dogs with canine infectious respiratory disease. J Clin Microbiol. 2013 Dec;51(12):4112-9. doi: 10.1128/JCM.02312-13. Epub 2013 Oct 2.
  • Hendricks CG, Levy JK, Tucker SJ, Olmstead SM, Crawford PC, Dubovi EJ, Hanlon CA. 2014. Tail vaccination in cats: a pilot study. J Feline Med Surg. 2014 Apr;16(4):275-80. doi: 10.1177/1098612X13505579. Epub 2013 Oct 9.
  • Slate D, Chipman RB, Algeo TP, Mills SA, Nelson KM, Croson CK, Dubovi EJ, Vercauteren K, Renshaw RW, Atwood T, Johnson S, Rupprecht CE. 2014. Safety and immunogenicity of Ontario rabies vaccine bait (ONRAB) in the first US field trial in raccoons (Procyon lotor). J Wildl Dis. 2014 Jul;50(3):582-95. doi: 10.7589/2013-08-207. Epub 2014 May 7.
  • Licitra BN, Whittaker GR, Dubovi EJ, Duhamel GE. 2014. Genotypic characterization of canine coronaviruese associated with fatal canine neonatal enteritis in the United States. J Clin Microbiol. 2014 Dec;52(12):4230-8. doi: 10.1128/JCM.02158-14. Epub 2014 Sep 24.
  • Dalziel BD, Huang K, Geoghegan JL, Arinaminpathy N, Dubovi EJ, Grenfell BT, Ellner SP, Holmes EC, Parrish CR. 2014. Contact heterogeneity, rather than transmission efficiency, limits the emergence and spread of canine influenza virus. PLoS Pathog. 2014 Oct 23;10(10):e1004455. doi: 10.1371/journal.ppat.1004455. eCollection 2014 Oct.
  • Khatibzadeh SM, Gold CB, Keggan AE, Perkins GA, Glaser AL, Dubovi EJ, Wagner B. 2015. West Nile virus-specific immunoglobulin isotype responses in vaccinated and infected horses. Am J Vet Res. 2015 Jan;76(1):92-100. doi: 10.2460/ajvr.76.1.92.
  • Viana M, Cleaveland S, Matthiopoulos J, Halliday J, Packer C, Craft ME, Hampson K, Czupryna A, Dobson AP, Dubovi EJ, Ernest E, Fyumagwa R, Hoare R, Hopcraft JG, Horton DL, Kaare MT, Kanellos T, Lankester F, Mentzel C, Mlengeya T, Mzimbiri I, Takahashi E, Willett B, Haydon DT, Lembo T. Dynamics of a morbillivirus at the domestic-wildlife interface: Canine distemper virus in domestic dogs and lions. Proc Natl Acad Sci USA. 2015 Feb 3; 112(5):1464-9. doi: 10.1073/pnas.1411623112.
  • Scheel TK, Kapoor A, Nishiuchi E, Brock KV, Yu Y, Andrus L, Gu M, Renshaw RW, Dubovi EJ, McDonough SP, Van de Walle GR, Lipkin WI, Divers TJ, Tennant BC, Rice.CM. Characterization of nonprimate hepacivirus and construction of a functional molecular clone. Proc Natl Acad Sci USA. 2015 Feb 17; 112(7):2192-7. doi:10.1073/pnas.1500265112.
  • Gaudreault NN, Jasperson DC, Dubovi EJ, Johnson DJ, Ostlund EN, Wilson WC. Whole genome sequence analysis of circulating Bluetongue Virus serotype 11 strains from the United States including two domestic canine isolates. J Vet Diagn Invest. 2015 Jun 11. pii: 1040638715585156.
  • Neill JD, Dubovi EJ, Ridpath HF. Identification of amino acid changes in the envelope glycoproteins of bovine viral diarrhea viruses isolated from alpaca that may be involved in host adaptation. Vet Microbiol. 2015 Jun 6. pii: S0378-1135(15)00243-6. doi: 10.1016/j.vetmic.2015.06.007.

Awards and Honors

American College of Veterinary Microbiologists - Elected Honorary Diplomate, November, 2000

Professional/Academic Affiliations

  • American Society for Microbiology
  • American Society for Virology
  • American Association of Veterinary Laboratory Diagnosticians
  • American Association for the Advancement of Science
  • United States Animal Health Association
  • Wildlife Diseases Association
  • Sigma Xi
  • Member, Foreign and Emerging Diseases, USAHA
  • Member, Infectious Diseases of Cattle, Bison and Camelids USAHA
  • Member, Virology Committee, American Association of Veterinary Laboratory Diagnosticians
  • Member, Bluetongue and Related Orbivirus, USAHA
  • Member, Bluetongue Diagnosis Committee, American Association of Veterinary Laboratory Diagnosticians.
  • Ad Hoc Reviewer for USDA Grants Program
  • Ad Hoc Reviewer for the Grayson-Jockey Club
  • Editorial Board - Journal of Clinical Microbiology, 1992-4.
  • Ad Hoc Reviewer for the following journals:
     

    Journal of Virology
    Journal of Infectious Diseases
    Veterinary Pathology
    Nucleic Acids
    The Compendium on Continuing Education for the Practicing Veterinarian
    Reviews of Infectious Diseases
    Virology
    Journal of General Virology
    Journal of Clinical Microbiology
    Veterinary Microbiology
    Archives of Virology
    Journal of Veterinary Diagnostic Investigation
    Journal of Zoo and Wildlife Medicine
    Journal of Wildlife Diseases
    Journal of Virological Methods
    Virus Research
    Theriogenology
    Vaccine
    Journal of American Veterinary Medical Association
    Canadian Journal of Veterinary Research