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Regional and cellular significance of the brain renin-angiotensin system (RAS) in hypertension

  • The brain RAS has long been considered pivotal in normal cardiovascular regulation and in the pathogenesis of neuro-cardiovascular diseases such as hypertension.
  • However, the questions of which genes, where in the brain, and what cell types are involved in these cardiovascular effects have remained a mystery due, in part, to a lack of appropriate experimental tools.
  • Much of our work has focused on dissecting the functional role of brain RAS genes and related molecules using an array of newly developed transgenic models and genomic techniques.
Cre-treated hAGTflox mice show reduced hAGT staining in SFO that parallels intense Cre staining in this site.
Selective ablation of angiotensinogen in the SFO prevents central renin-induced cardiovascular responses.

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