Welcome to the Simpson Lab! We are a small lab group located in the Clinical Sciences Department at Cornell's School of Veterinary Medicine in Ithaca, NY. We specialize in gastrointestinal disease with a focus on host-bacterial interactions. We also offer diagnostic services in the form of fluorescent in-situ hybridization (FISH).
The work of the Simpson laboratory is focused principally on host-bacterial interactions in the gastrointestinal tract. We are interested in the role of the enteric microflora in inflammatory bowel diseases, and bacterial infections in other gastrointestinal disorders such as hepatobiliary disease and pancreatitis. We have a long-standing interest in the role of Helicobacter in gastrointestinal inflammation and cholangitis. Our more recent studies have explored the role of the resident enteric flora in inflammatory bowel diseases across species, and in-depth characterization of an emergent group of Adherent and Invasive E. coli associated with granulomatous colitis in Boxer dogs, and Crohn's disease in people.