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Gerlinde Van de Walle, DVM, PhD

Dr. Gerlinde Van de Walle

Department of Microbiology and Immunology

Baker Institute for Animal Health

Harry M. Zweig Assistant Professor in Equine Health

Baker Institute for Animal Health

Lab Website


Baker Institute for Animal Health
235 Hungerford Hill Road
Ithaca, NY 14853

Department of Microbiology and Immunology
Cornell University College of Veterinary Medicine
C5 171 Veterinary Medical Center
Ithaca, NY 14853


Office: 607.256.5608
Email: grv23@cornell.edu

Research Interest

The objective of Dr. Gerlinde Van de Walle’s research is to open up new avenues towards therapeutic intervention by better understanding the pathogenesis of diseases important to veterinary and human medicine. To this end, our lab uses various model systems, including in vitro 2D cell cultures, ex vivo 3D explant and organoid models, and in vivo rodent and large animal models.

Viral pathogenesis: Many veterinary species are naturally susceptible to pathogens closely related to those that infect humans.  Since these animal and human pathogens frequently share similar pathogenesis profiles, animal diseases might be considered translational models for their human counterparts. The viruses we currently study are equine hepatitis-associated viruses, equine herpesviruses, and feline herpesvirus type 1.

Stem cell biology: Our research group studies the basic physiology of adult stem cells as well as their potential in regenerative medicine. For example, we use a unique tool set consisting of mammary stem cell/progenitor cells (MaSC) from a variety of mammalian species, for comparative studies on the underlying molecular basis of susceptibility and resistance towards mammary/breast cancer. Stem cells also secrete a collection of bioactive factors, referred to as “the secretome”, which represents a new source to identify molecules with therapeutic potential. We are exploring the potential of the adult stem cell secretome to promote wound healing and fight infections.

Education

1999 - DVM, Ghent University, Belgium
2003 - Ph.D., Ghent University, Belgium

Biography/Professional Experience

  • 2000–2003 Graduate Research Assistant in the laboratory of Dr. Hans Nauwynck, Department of Virology, Parasitology & Immunology, Ghent University, Belgium
  • 2003–2005 Postdoctoral Researcher in the laboratory of Dr. Hans Deckmyn, Laboratory of Thrombosis Research, University of Leuven, Belgium
  • 2006–2008 Postdoctoral Associate in the laboratory of Dr. Nikolaus Osterrieder, Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University
  • 2008–2011 Postdoctoral Research Fellow in the laboratory of Dr. Hans Nauwynck, Department of Virology, Parasitology & Immunology, Ghent University, Belgium
  • 2010–2012 Assistant Professor (docent), Department of Comparative Physiology and Biometrics, Ghent University, Belgium
  • 2013–present Assistant Professor, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University

Selected Publications

Links and abstracts for all of Dr. Van de Walle’s publications can be found at PubMed.

1. Harman, RM; Yang, S; He, MK; Van de Walle, GR. (2017). Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin woundsStem Cell Research & Therapy, 8(1).

2. Harman, RM; Bihun, IV; Van de Walle, GR. (2017). Secreted factors from equine mesenchymal stromal cells diminish the effects of TGF-β1 on equine dermal fibroblasts and alter the phenotype of dermal fibroblasts isolated from cutaneous fibroproliferative woundsWound Repair and Regeneration, 25(2), 234-47.

3. Pennington, MR; Van de Walle, GR. (2017). Electric Cell-Substrate Impedance Sensing To Monitor Viral Growth and Study Cellular Responses to Infection with Alphaherpesviruses in Real TimemSphere, 2(2).

4. Bussche, L; Rauner, G; Antonyak, M; Syracuse, B; McDowell, M; Brown, AM; Cerione, RA; Van de Walle, GR. (2016). Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell GrowthThe Journal of Biological Chemistry, 291(47), 24390-24405.

5. Pennington, MR; Curtis, TM; Divers, TJ; Wagner, B; Ness, SL; Tennant, BC; Van De Walle GR. (2016). Equine Mesenchymal Stromal Cells from Different Sources Efficiently Differentiate into Hepatocyte-Like CellsTissue Engineering: Part C, 22(6), 596-607.

6. Pennington, MR; Fort, MW; Ledbetter, EC; Van de Walle, GR. (2016). A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1)The Journal of General Virology, 97(6), 1414-25.

7. Bussche, L; Harman, RM; Syracuse, BA; Plante, EL; Lu, YC; Curtis, TM; Ma, M; Van de Walle, GR. (2015). Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitroStem Cell Research & Therapy, 6:66.

Awards and Honors

  • 2006 Stephen Straus travel Award for the 31th International Herpes Workshop (IHW), Seattle
  • 2008 – 2011 Postdoctoral research fellowship from the Research Foundation Flanders
  • 2014 Burroughs Wellcome Fund for the Merial-NIH Veterinary Scholars Symposium, Ithaca
  • 2014 – present Atkinson Center for a Sustainable Future Faculty Fellow
  • 2016 Zoetis Award for Excellence in Veterinary Research

Professional/Academic Affiliations

  • 2010 - 2012 Belgian Society for Microbiology
  • 2010 - 2012 Belgian Environmental Mutagen Society
  • 2010 - 2012 Belgian Society of Physiology and Pharmacology
  • 2010 - 2012 European Society for Veterinary Virology
  • 2013 - present American Society for Microbiology
  • 2013 - present American Society for Virology
  • 2013-present International Society for Stem Cell Research
  • 2013 - present Cornell University Stem Cell Program
  • 2014 - present Cornell Comparative Cancer Biology Training Program
  • 2015 - present New York State Veterinary Medical Society
  • 2015 - present Meyer Cancer Center at Weill Cornell Medicine

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