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Paul Soloway, PhD

Paul Soloway, PhD

Department of Biomedical Sciences

Professor of Molecular Genetics
Chair

Lab Website


Department of Biomedical Sciences
Cornell University College of Veterinary Medicine
T4 018 Veterinary Research Tower
Ithaca, NY 14853-6401

Office: 607-253-3336
Fax: 607-253-4447
Email: soloway@cornell.edu

Research Interest

Welcome to the Soloway Lab at Cornell University where we study epigenetic phenomena in mammals. The term epigenetics is attributed to Conrad Hal Waddington, who used it in the early 1950's to describe environmentally induced, nongenetic changes in traits.  The "epi" prefix emphasizes that mechanisms exist that influence traits which are distinct from genetic mechanisms.  Because epigenetic phenomena are reversible at a much higher rate than genetic mutations, they may play a special role in evolutionary processes.

At the molecular level, epigenetics regulatory mechanisms involve methylation of cytosines in DNA, at least six modifications placed at many positions at the N-termini of histones, and an emerging class of processes influenced by non-coding RNAs.  Proper control of these modifications and regulatory mechanisms is essential for the most fundamental biological processes including gene expression, stem cell development and differentiation, DNA repair and recombination, and a variety of complex traits dependent on these processes.  When normal epigenetic control is lost, disease can arise.  This has been best characterized in cancers, many of which develop and progress in part because of failed epigenetic control.  Epigenetic status of our genome is influenced by environmental variables, including nutrients in our diets. 

Interests of the lab include understanding how it is that epigenetic states are controlled, particularly in the germ line; and determining how epigenetic states vary in the nervous system when experimental animals are exposed to environmental conditions that influence their cognitive and behavioral states.  We also seek to develop novel experimental tools that will augment the discovery process.  

Education

  • Postdoctoral Fellow, Whitehead Institute, 1990-1994 (Advisor: Rudolf Jaenisch)
  • Postdoctoral Fellow, Department of Biology, MIT 1990-1994 (Advisor: Malcolm Gefter)
  • PhD, Molecular Biology, Princeton University, 1989 (Advisor: Thomas E. Shenk)
  • BA, Department of Biochemistry, Cornell University, 1979

Biography/Professional Experience

  • 2017-Present     Professor of Molecular Genetics and Chair, Dept. of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY
  • 2005-Present     Professor, Division of Nutritional Sciences, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY
  • 2002-2005     Associate Professor, Division of Nutritional Sciences, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY
  • 2002-2005     Adjunct Member, Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY
  • 1999-2002     Cancer Research Scientist IV, Associate Member, Dept. of Molecular and Cellular Biology; Director, Transgenic and Gene Targeting Facility, Roswell Park Cancer Institute, Buffalo, NY
  • 1998-1999     Cancer Research Scientist IV, Assistant Member, Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY
  • 1994-1998     Cancer Research Scientist III, Assistant Member, Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY
  • 1979-1981     Lab Technician, Dept. of Agricultural Engineering, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY

Publications

Professional/Academic Affiliations

  • Scientific Advisory Board Member, Foundation for Angelman Syndrome Therapeutics
  • Editorial Board, Frontiers in Nutrigenomics
  • Member, NIH GHD Study Section

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