Sergiy Libert, PhD
Most living organisms, including humans, age. Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death. Work in model organisms has demonstrated that genetic and environmental manipulations can prevent numerous age-associated diseases, improve health at advanced age, and increase life span.
My laboratory uses a diverse range of techniques to study the process of aging. We use mouse models, cell culture, biochemistry, and computational methods to better understand normal and pathological process that accompany human aging, and to develop interventions to delay aging and ameliorate age-related diseases such as cancer, metabolic syndrome, and neuro-degeneration.
- Postdoctoral Fellow, MIT
- PhD, Baylor College of Medicine
- Masters, Physics, Clarkson University
- Sergiy Libert, Kelli Pointer, Michael Bonkowski, Scott D. Pletcher, Leonard Guarente, Deviation of innate circadian period from 24 hours reduces longevity in mice, Aging Cell, 2012, Oct;11(5):794-800
- Sergiy Libert, Kelli Pointer, Eric L. Bell, Abhirup Das, Dena Cohen, John M. Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa, Kenneth S. Kendler, Xiangning Chen, John M. Hettema, Edwin J. van den Oord, Justin P. Rubio, Leonard Guarente, SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive, Cell, 2011, Dec 23; 147:1–14.
- Sergiy Libert, Jessica Zwiener, Xiaoween Chu, Wayne VanVoorhies, Gregg Roman, Scott D. Pletcher, Regulation of Drosophila lifespan by olfaction and food-derived odors, Science, 2007, Feb (315), 1133-7.
- Sergiy Libert, Yufang Chao, Jessica Zwiener, Scott D. Pletcher, Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction, Molecular Immunology, 2008, Feb; 45(3):810-7.
Awards and Honors